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C1-inhibitor autoantibodies in SLE.

T Mészáros¹, G Füst, H Farkas

¹3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.

|January 15, 2010

Summary

Autoantibodies to C1-inhibitor (anti-C1-INH) are more prevalent in systemic lupus erythematosus (SLE) patients than healthy individuals. Elevated anti-C1-INH levels in SLE correlate with disease duration and activity.

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

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Area of Science:

Immunology
Rheumatology

Background:

Acquired C1-inhibitor deficiency is characterized by anti-C1-inhibitor (anti-C1-INH) autoantibodies.
Data on the prevalence and significance of anti-C1-INH in systemic lupus erythematosus (SLE) are limited.

Purpose of the Study:

To investigate the prevalence and diagnostic value of anti-C1-INH autoantibodies in SLE patients.
To explore the correlation between anti-C1-INH levels and clinical/laboratory parameters in SLE.

Main Methods:

A multicentre study involving 202 SLE patients and 134 healthy controls.
Measurement of anti-C1-INH IgG levels in sera.
Analysis of clinical data, including organ involvement, SLEDAI score, and disease duration.
Assessment of other immunological markers like anti-C1q, anti-dsDNA, and complement levels (C3, C4).

Main Results:

SLE patients exhibited significantly higher anti-C1-INH IgG levels compared to controls (p = 0.034).
Elevated anti-C1-INH levels (> or =0.4 U/ml) were detected in 17% of SLE patients versus 4% of controls (p = 0.0003).
Higher anti-C1-INH levels were associated with increased SLEDAI scores (p = 0.048) and longer disease duration (p = 0.0004).

Conclusions:

Anti-C1-INH autoantibodies are more common in SLE patients than in healthy individuals.
Elevated anti-C1-INH levels in SLE correlate with disease activity and chronicity.
Further research may elucidate the specific role of anti-C1-INH in SLE pathogenesis.