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Related Experiment Video

Updated: Jun 17, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

In vivo endoscopic multi-beam optical coherence tomography.

Beau A Standish¹, Kenneth K C Lee, Adrian Mariampillai

¹Deptartment of Medical Biophysics, University of Toronto, Toronto, Canada. standish@ee.ryerson.ca

Physics in Medicine and Biology

|January 15, 2010

Summary

A novel multichannel optical coherence tomography (OCT) system with an endoscopic probe offers high-resolution imaging. This swept-source OCT technology shows potential for in vivo human endoscopic applications.

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Area of Science:

Biomedical Optics
Medical Imaging
Optical Engineering

Background:

Optical Coherence Tomography (OCT) is a valuable non-invasive imaging modality.
Existing OCT systems can face limitations in resolution and signal intensity for endoscopic applications.

Purpose of the Study:

To develop a multichannel optical coherence tomography (multi-beam OCT) system with an in vivo endoscopic imaging probe.
To achieve high transverse resolution and increased signal intensity for improved in vivo imaging.

Main Methods:

Developed a swept-source OCT system integrated with a micro-machined distal optics fiber optic array.
Engineered a multi-focus fiber optic array to achieve a high numerical aperture.
Utilized the system for pre-clinical in vivo imaging of rabbit colon and ex vivo imaging of esophagus and trachea.

Main Results:

Achieved a transverse resolution of <10 microm full width half maximum (FWHM) across the entire imaging range.
Increased signal intensity within the focus of individual channels.
Demonstrated good correlation between multi-beam OCT images and H&E histology.

Conclusions:

The developed multi-beam OCT system with an endoscopic probe provides high-resolution structural imaging.
The system shows significant potential for future in vivo human endoscopic imaging applications.