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Protective role of Annona squamosa linn bark extracts in DMBA induced genotoxicity

K Suresh1, S Manoharn, D Blessy

  • 1Department of Biochemistry and Biotechnology, Faculty of science, Annamalai University, Tamil Nadu, India. suraj_cks@yahoo.co.in

Kathmandu University Medical Journal (KUMJ)
|January 15, 2010
PubMed
Abstract

Insights

Annona squamosa bark extracts show protective effects against genotoxicity induced by 7,12 dimethylbenz(a)anthracene (DMBA). The ethanolic extract demonstrated a stronger antigenotoxic effect in golden Syrian hamsters.

Area of Science:

  • Toxicology
  • Pharmacology
  • Natural Product Research

Background:

  • Genotoxic agents like 7,12-dimethylbenz(a)anthracene (DMBA) are implicated in cancer development.
  • DMBA is a potent carcinogen known to induce mutagenic effects.
  • Annona squamosa holds a traditional medicinal role in treating various ailments, including cancer.

Purpose of the Study:

  • To evaluate the antigenotoxic potential of Annona squamosa bark extracts.
  • To investigate the protective effects against DMBA-induced genotoxicity in golden Syrian hamsters.

Main Methods:

  • Genotoxicity was induced in golden Syrian hamsters via DMBA injection.
  • Aqueous and ethanolic Annona squamosa bark extracts were administered orally.
  • Antigenotoxic effects were measured by analyzing micronucleated polychromatic erythrocytes (MnPCEs) and chromosomal aberrations.

Main Results:

  • DMBA treatment significantly increased MnPCEs and chromosomal aberrations compared to controls.
  • Oral administration of both aqueous and ethanolic Annona squamosa extracts markedly reduced these genotoxic markers.
  • The ethanolic extract exhibited a more pronounced protective effect than the aqueous extract.

Conclusions:

  • Annona squamosa bark extracts possess significant antigenotoxic properties.
  • The ethanolic extract of Annona squamosa demonstrates superior protection against DMBA-induced genotoxicity.
  • These findings support the traditional use of Annona squamosa and highlight its potential as a chemopreventive agent.

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