Antivascular therapy for epithelial ovarian cancer

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Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
07:59

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

Francois P Duhoux1, Jean-Pascal Machiels

  • 1Centre du Cancer, Department of Medical Oncology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.

Journal of Oncology
|January 15, 2010
PubMed

Insights

New ovarian cancer therapies target tumor blood vessels. Antiangiogenic and vascular-disrupting strategies show promise in early trials, with results from larger studies anticipated.

Area of Science:

  • Oncology
  • Vascular Biology

Background:

  • Ovarian cancer is a leading cause of cancer death in women.
  • Tumor angiogenesis, driven by an angiogenic factor imbalance, is crucial in ovarian cancer.
  • Novel targeted therapies are being explored to combat this disease.

Purpose of the Study:

  • To review novel antivascular treatments for ovarian cancer.
  • To discuss antiangiogenic and vascular-disrupting therapies targeting tumor vasculature.

Main Methods:

  • Comprehensive literature review of targeted therapies for ovarian cancer.
  • Analysis of current research on antiangiogenic and vascular-disrupting agents.

Main Results:

  • Ovarian cancer exhibits an imbalance favoring angiogenesis.
  • Various antivascular strategies are under investigation.
  • Phase II trials show promising activity for these novel therapies.

Conclusions:

  • Targeting tumor vasculature is a key strategy in ovarian cancer treatment.
  • Further clinical trials (Phase III) are needed to confirm efficacy.

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