Related Experiment Video

Updated: Jun 17, 2026

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
10:24

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

Combined cases of polypoidal choroidal vasculopathy and typical age-related macular degeneration

Ichiro Maruko1, Tomohiro Iida, Masaaki Saito

  • 1Department of Ophthalmology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1247, Japan. imaruko@fmu.ac.jp

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|January 15, 2010
PubMed
Abstract

Insights

Combined cases of polypoidal choroidal vasculopathy (PCV) and typical age-related macular degeneration (AMD) suggest these conditions may overlap. Further research is needed to understand the relationship between PCV and typical AMD progression.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Macular Degeneration

Background:

  • Age-related macular degeneration (AMD) is a leading cause of vision loss.
  • Neovascular AMD can manifest as polypoidal choroidal vasculopathy (PCV), typical AMD, or retinal angiomatous proliferation (RAP).
  • Previous studies identified combined AMD cases, where one eye exhibits PCV and the other typical AMD.

Observation:

  • This study investigated 20 patients (5.7%) with one eye diagnosed with PCV and the other with typical AMD.
  • Initial best-corrected visual acuity differed between PCV (0.20) and typical AMD (0.43) eyes.
  • Fluorescein and indocyanine green angiography (FA and ICGA) were used for diagnosis and monitoring.

Findings:

  • During a mean follow-up of 21.7 months, ten eyes initially diagnosed with typical AMD developed PCV.
  • Typical AMD eyes exhibited both classic and occult choroidal neovascularization (CNV) on FA.
  • The average age of patients with combined AMD types was 73 years.

Implications:

  • The findings suggest that PCV and typical AMD are not distinct entities and may represent overlapping stages of the same disease.
  • Understanding this overlap is crucial for accurate diagnosis and treatment strategies in neovascular AMD.
  • Further investigation into the progression and potential transformation between PCV and typical AMD is warranted.

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