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LIBS-based detection of antioxidant elements: a new strategy.

Geeta Watal1, Bechan Sharma, Prashant Kumar Rai

  • 1Department of Biochemistry, University of Allahabad, Allahabad, India. geetawatal@gmail.com

Methods in Molecular Biology (Clifton, N.J.)
|January 15, 2010
PubMed
Summary

The aqueous extract of Trichosanthes dioica fruits effectively combats diabetes-induced oxidative stress by reducing lipid peroxidation and enhancing antioxidant enzymes. Key minerals like calcium, magnesium, and iron in the extract contribute to its potent antioxidant activity.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Analytical Chemistry

Background:

  • Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and increased oxidative stress.
  • Oxidative stress, an imbalance between reactive oxygen species and antioxidants, plays a crucial role in diabetic complications.
  • Trichosanthes dioica, a traditional medicinal plant, is explored for its potential therapeutic benefits.

Purpose of the Study:

  • To scientifically evaluate the antioxidant potential of the aqueous extract of Trichosanthes dioica fruits.
  • To investigate the effect of the extract on diabetes-induced oxidative stress in a rat model.
  • To identify key elemental components contributing to the extract's antioxidant activity.

Main Methods:

  • Induction of diabetes and administration of Trichosanthes dioica fruit aqueous extract to rats.

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  • Analysis of oxidative stress markers, including lipid peroxidation (LPO) and antioxidant enzymes (CAT, SOD, GPx, GST).
  • Elemental analysis of the extract using Laser-Induced Breakdown Spectroscopy (LIBS).

    • Main Results:

    • The extract significantly reduced elevated lipid peroxidation levels in diabetic rats (p < 0.05).
    • Activities of antioxidant enzymes (CAT, SOD, GPx, GST) were significantly increased in treated diabetic rats (p < 0.05).
    • LIBS detected significant concentrations of Ca(2+), Mg(2+), and Fe(2+) in the extract, correlating with its antioxidant properties.

    Conclusions:

    • The aqueous extract of Trichosanthes dioica fruits exhibits significant antioxidant potential against diabetes-induced oxidative stress.
    • The observed therapeutic effects are attributed to the extract's ability to restore redox balance and its rich mineral content.
    • Trichosanthes dioica represents a promising natural source for managing oxidative stress in diabetes.