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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Published on: November 4, 2010

siRNA as a therapy for asthma.

Hsin-Ying Huang1, Bor-Luen Chiang

  • 1National Taiwan University, Graduate Institute of Immunology, College of Medicine, 1 Jen-Ai Road, Section 1, Taipei, 100, Taiwan.

Current Opinion in Molecular Therapeutics
|January 15, 2010
PubMed
Summary

RNA interference (RNAi) offers a promising therapeutic strategy for allergic asthma by silencing specific genes. This review explores RNAi

Area of Science:

  • Immunology
  • Molecular Biology
  • Pharmacology

Background:

  • RNA interference (RNAi) is a mechanism for sequence-specific gene silencing using small interfering RNA (siRNA).
  • RNAi is widely used for gene expression control and shows therapeutic potential for diseases like cancer and viral infections.
  • Gene therapy for asthma has shown promise in animal models, with recent advancements in siRNA delivery to the respiratory system enhancing feasibility.

Purpose of the Study:

  • To review the mechanism, strategies, and challenges of in vivo RNA interference (RNAi).
  • To focus on the potential of RNAi for alleviating airway inflammation in allergic asthma.
  • To summarize data on siRNA targeting molecules in allergic responses and discuss RNAi's therapeutic potential and limitations.

Main Methods:

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  • Review of existing literature on RNA interference (RNAi) mechanisms.
  • Analysis of studies employing small interfering RNA (siRNA) against targets in allergic responses.
  • Discussion of in vivo application strategies and challenges for RNAi therapy.

Main Results:

  • RNA interference (RNAi) demonstrates potential for controlling gene expression relevant to allergic asthma.
  • Successful siRNA delivery to the respiratory system improves the therapeutic feasibility of RNAi for asthma.
  • Studies show siRNA targeting molecules involved in allergic responses offer a novel therapeutic avenue.

Conclusions:

  • RNA interference (RNAi) presents a promising novel therapeutic approach for allergic asthma.
  • Further research into in vivo application strategies and challenges is needed.
  • RNAi holds significant potential for alleviating airway inflammation and treating asthma.