[Perfusion by magnetic resonance imaging: its physical foundations and clinical application]
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Updated: Jun 17, 2026
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Nicolás Fayed-Miguel1, Julio Castillo-Blandino, Jaime Medrano-Lin
1Servicio de Neurorradiología, Hospital Quirón, Zaragoza, España. nicola33fr@yahoo.es
Aims:
We review one of the most important functional techniques in magnetic resonance imaging, perfusion MRI (pMRI) with emphasis in its applications, particularly in the diagnosis and follow up of brain lesions. First, we discuss the physical principles and results of the technique, then, we discuss its major applications.
Development And Conclusions:
In clinical settings, two different contrast-based MRI techniques are used: T2*-weighted dynamic susceptibility contrast MRI (DSC) and T1-weighted dynamic contrast enhancement imaging (DCE). DSC measures the pharmacokinetics of first pass contrast bolus through a predefined volume. In contrast, DCE measures capillary permeability, derived it from an assumed compartment model in a time-series of T1-weighted images. The major usefulness of pMRI has been reported in brain tumors, brain ischemia and inflammation, and degenerative disorders. In this paper we review the physical basis and the contribution of MRI perfusion to the diagnosis and prognosis of several diseases of the central nervous system.
Insights
Perfusion MRI (pMRI) is a key functional MRI technique for diagnosing and monitoring brain lesions. This review covers its principles, applications in conditions like tumors and ischemia, and its diagnostic value.
Area of Science:
- Neuroimaging
- Functional MRI
- Medical Physics
Context:
- Magnetic Resonance Imaging (MRI) is a cornerstone of modern diagnostics.
- Perfusion MRI (pMRI) offers functional insights beyond anatomical imaging.
- Brain lesions require accurate and timely diagnosis for effective management.
Purpose:
- To review the physical principles and technical aspects of perfusion MRI.
- To highlight the clinical applications of pMRI in diagnosing and monitoring brain lesions.
- To discuss the contribution of pMRI to the understanding of central nervous system diseases.
Summary:
- Perfusion MRI (pMRI) utilizes contrast agents to assess blood flow and tissue perfusion.
- Two primary techniques, Dynamic Susceptibility Contrast (DSC) and Dynamic Contrast Enhancement (DCE), are employed.
- pMRI is particularly valuable in the diagnosis and follow-up of brain tumors, ischemia, inflammation, and degenerative disorders.
Impact:
- pMRI enhances diagnostic accuracy for various neurological conditions.
- It aids in the prognosis and management of brain pathologies.
- This review provides a comprehensive overview for clinicians and researchers in neuroimaging.
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