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[Paget's disease and hypercalcemia: coincidence or causal relationship?]
1Family Medicine Department, IDF, Sheba Medical Center, Tel Hashomer. ilangreen.md@gmail.com
Harefuah
|January 16, 2010
Summary
Paget
Area of Science:
- Endocrinology
- Orthopedics
- Bone Metabolism
Background:
- Paget's disease is a chronic bone disorder characterized by disordered bone remodeling.
- Hypercalcemia is an uncommon complication of Paget's disease, often necessitating the exclusion of primary hyperparathyroidism.
- Genetic and viral factors are implicated in the etiology of Paget's disease.
Observation:
- A case study of a patient with Paget's disease presenting with hypercalcemia.
- The patient was found to have a parathyroid adenoma, a cause of hypercalcemia.
Findings:
- Parathyroid adenoma removal improved calcium and alkaline phosphatase (ALP) levels in Paget's disease patients.
- Clinical symptom improvement was observed only in patients with pre-operative hypercalcemia, suggesting a link between parathyroid hormone (PTH) sensitivity and Paget's disease symptoms.
Implications:
- Hyperparathyroidism is the primary cause of hypercalcemia in Paget's disease.
- Surgical management of parathyroid adenomas can alleviate biochemical and, in select cases, clinical manifestations of Paget's disease.
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