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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
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A study of intima media thickness and their cardiovascular risk factors in patients with psoriatic arthritis

Sadhanah Aqashiah Mazlan1, Mohd Shahrir bin Mohamed Said, Heselynn Hussein

  • 1Hospital Ampang, Medical Department, Kuala Lumpur, Malaysia.

Acta Medica (Hradec Kralove)
|January 16, 2010
PubMed

Insights

Psoriatic arthritis patients show increased carotid intima media thickness, a marker of atherosclerosis. Age, hypertension, and metabolic syndrome are key predictors, not disease activity.

Area of Science:

  • Rheumatology
  • Cardiology
  • Vascular Ultrasound

Background:

  • Psoriatic arthritis (PsA) is an inflammatory condition linked to psoriasis.
  • Cardiovascular disease (CVD) risk in PsA patients requires further investigation.
  • Carotid intima media thickness (CIMT) is a sensitive indicator of subclinical atherosclerosis.

Purpose of the Study:

  • To determine the prevalence of CIMT in Malaysian PsA patients.
  • To identify associations between CIMT and disease activity or predictors.
  • To assess subclinical atherosclerosis in PsA.

Main Methods:

  • 63 PsA patients meeting CASPAR criteria were recruited.
  • High-resolution B-mode ultrasound measured common carotid intima media thickness (IMT).
  • A cross-sectional study design was employed.

Main Results:

  • 15.9% of PsA patients had positive IMT (>1.00 mm).
  • Significant associations found with age, waist circumference, hypertension, diabetes, and metabolic syndrome.
  • Age was the sole independent predictor of positive IMT (OR 1.116).

Conclusions:

  • CIMT is associated with cardiovascular risk factors in PsA patients.
  • No association was found between CIMT and PsA disease activity, severity, or DMARDs therapy.
  • This study highlights the importance of assessing cardiovascular risk in PsA.
Abstract

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