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Updated: Jun 17, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Craniofacial morphology in preschool children with obstructive sleep apnoea syndrome
A Marino1, I Malagnino, R Ranieri
1Sapienza University of Rome, 2nd Medical Faculty, Sant'Andrea Hospital, Dentistry and Orthodontics Unit, Rome, Italy. alessandramarinoit@yahoo.it
Insights
Preschool children with obstructive sleep apnoea syndrome (OSAS) often exhibit a skeletal Class II pattern. This pattern is characterized by a retrognathic mandible and increased skeletal divergency, impacting craniofacial development.
Area of Science:
- Pediatric Sleep Medicine
- Craniofacial Orthodontics
- Respiratory Medicine
Background:
- Obstructive sleep apnoea syndrome (OSAS) is a prevalent condition in children, marked by airway obstruction, hypoxemia, and disrupted sleep.
- OSAS significantly impacts normal ventilation and sleep patterns in affected children.
Purpose of the Study:
- To investigate the craniofacial characteristics of preschool children diagnosed with OSAS.
- Utilize standardized lateral cephalograms and floating norms cephalometric analysis for evaluation.
Main Methods:
- Inclusion of 21 untreated Caucasian preschool children (mean age 4.57 years) with complete deciduous dentition.
- All subjects had a polysomnographic diagnosis of OSAS with a positive Respiratory Disturbance Index (RDI).
- Evaluation of pretreatment cephalometric radiographs using descriptive statistics (mean and standard deviation).
Main Results:
- Preschool children with OSAS demonstrated a skeletal Class II pattern.
- A retrognathic mandible was a common finding in the OSAS group.
- Increased skeletal divergency was observed in children with OSAS.
Conclusions:
- The study identified specific craniofacial features associated with OSAS in preschool children.
- Findings suggest a link between OSAS and a Class II skeletal pattern, retrognathic mandible, and increased divergency.
Aim:
Obstructive sleep apnoea syndrome (OSAS) is a common problem in children. It is characterised by a combination of partial airway obstruction associated with hypoxemia and hypoventilation and intermittent obstructive apnoea, which disrupts normal ventilation and sleep. The aim of the study was to evaluate the craniofacial features of preschool children with polysomnographic diagnosis of OSAS, using measurements from standardized lateral cephalograms according to the floating norms cephalometric analysis.
Materials And Methods:
21 untreated caucasian children (mean age of 4.57 +/-0.6) with complete deciduous dentition were included in this study. All the subjects had diagnosis of OSAS with a positive RDI. Pretreatment cephalometric radiographs were evaluated. Statistical method Descriptive statistics includes mean and standard deviation of the cephalometric variables.
Conclusion:
The present study showed that OSAS preschool children showed a skeletal Class II pattern with retrognathic mandible and increased skeletal divergency.
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