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Published on: September 17, 2012
The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions
Eusebio Manchado1, Manuel Eguren, Marcos Malumbres
1Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, E-28029 Madrid, Spain.
Biochemical Society Transactions
|January 16, 2010
Summary
The anaphase-promoting complex/cyclosome (APC/C) is crucial for cell division and has emerging roles in neuronal function. Modulating APC/C activity may offer therapeutic benefits for various conditions.
Area of Science:
- Cell Biology
- Molecular Biology
- Neuroscience
Background:
- The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase essential for cell cycle progression.
- APC/C activity is regulated by cofactors Cdc20 and Cdh1, controlling substrate ubiquitination and degradation.
- APC/C is a known target of the spindle assembly checkpoint (SAC) during mitosis.
Purpose of the Study:
- To explore the established and emerging functions of APC/C.
- To highlight the role of APC/C in both cell proliferation and neuronal physiology.
- To investigate the potential of modulating APC/C activity for clinical applications.
Main Methods:
- Literature review of APC/C functions.
- Analysis of APC/C's role in mitosis and DNA replication.
- Examination of recent findings on APC/C in non-mitotic cells, particularly neurons.
Main Results:
- APC/C plays critical roles in regulating protein levels of mitotic and DNA replication regulators.
- Emerging evidence suggests cell-cycle-independent functions of APC/C in neuronal structure and function.
- APC/C's involvement spans fundamental cell processes and specialized cellular physiology.
Conclusions:
- APC/C is a key regulator with established roles in cell division and newly discovered functions in neurons.
- Understanding APC/C's diverse functions is vital for comprehending cell proliferation and neuronal health.
- Targeting APC/C activity presents a promising avenue for developing novel therapeutic strategies.
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