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Updated: Jun 17, 2026

Subcellular Imaging of Neuronal Calcium Handling In Vivo
Published on: March 17, 2023
Role of neuronal Ca2+-sensor proteins in Golgi-cell-surface membrane traffic
Marina Mikhaylova1, Pasham Parameshwar Reddy, Michael R Kreutz
1Project Group Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany. mikhaylova@ifn-magdeburg.de
Abstract:
The regulated local synthesis of PtdIns4P and PtdIns(4,5)P(2) is crucial for TGN (trans-Golgi network)-plasma membrane trafficking. The activity of PI4Kbeta (phosphoinositide 4-kinase IIIbeta) at the Golgi membrane is a first mandatory step in this process. In addition to PI4Kbeta activity, elevated Ca(2+) levels are also needed for the exit of vesicles from the TGN. The reason for this Ca(2+) requirement is at present unclear. In the present review, we discuss the role of neuronal Ca(2+)-sensor proteins in the regulation of PI4Kbeta and suggest that this regulation might impose a need for elevated Ca(2+) levels for a late step of vesicle assembly.
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