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Updated: Jun 17, 2026
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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Regulation of cyclin D1 gene expression
Ini-Isabée Witzel1, Li Fang Koh, Neil D Perkins
1Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK.
Biochemical Society Transactions
|January 16, 2010
Summary
This study explores how nuclear factor kappaB (NF-kappaB)/IkappaB kinase (IKK) pathways regulate cyclin D1 gene transcription. It also highlights the SNIP1/SkIP-associated RNA processing (SNARP) complex
Area of Science:
- Molecular Biology
- Cell Biology
- Cancer Research
Background:
- Cyclin D1 is a critical regulator of cell proliferation.
- Its expression is controlled by transcriptional and post-transcriptional mechanisms.
- Disregulation of cyclin D1 contributes to cancer development.
Purpose of the Study:
- To discuss the role of NF-kappaB/IKK pathways in cyclin D1 gene transcription.
- To introduce the SNARP complex as a novel regulator of cyclin D1 RNA stability.
Main Methods:
- Review of existing literature on cyclin D1 regulation.
- Discussion of molecular pathways involved in gene transcription and RNA stability.
Main Results:
- NF-kappaB/IKK pathways are key regulators of cyclin D1 gene transcription.
- The SNARP complex acts as a co-transcriptional regulator influencing cyclin D1 RNA stability.
Conclusions:
- Multiple pathways, including NF-kappaB/IKK and SNARP, intricately regulate cyclin D1 expression.
- Understanding these regulatory mechanisms is crucial for targeting cyclin D1 in tumorigenesis.
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