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Updated: Jun 17, 2026

In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
Published on: December 2, 2012
Echovirus-4 meningitis outbreak imported from India
Federico Gobbi1, Guido Calleri, Claudia Spezia
1Centre for Tropical Diseases, S. Cuore Hospital, Negrar, Verona Province, Italy. fedgobbi@tin.it
Abstract:
We describe seven cases of meningitis in a group of young Italian travelers coming back from India. Virologic studies identified echovirus-4 as the cause of this cluster of cases, the first imported echovirus outbreak in Italy. Enteroviruses may play an important role in undiagnosed fevers in travelers.
Insights
Seven young Italian travelers developed meningitis after returning from India. Virologic studies confirmed echovirus-4 as the cause, marking the first imported echovirus outbreak in Italy and highlighting enteroviruses in traveler fevers.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Background:
- Travelers returning from endemic regions are at risk for infectious diseases.
- Enteroviruses are a common cause of febrile illness, particularly in children.
- Imported viral outbreaks pose a challenge to public health surveillance.
Observation:
- Seven young Italian travelers returning from India presented with meningitis.
- Clinical presentation was consistent with viral meningitis.
- A cluster of cases suggested a common source of infection.
Findings:
- Virologic studies identified echovirus-4 as the causative agent.
- This represents the first documented imported echovirus outbreak in Italy.
- Echovirus-4 was confirmed through molecular and serologic testing.
Implications:
- Enteroviruses should be considered in the differential diagnosis of undiagnosed fevers in travelers.
- Enhanced surveillance for imported viral infections is crucial.
- Understanding travel-related infectious disease transmission is vital for prevention.
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