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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jun 17, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

miRMaid: a unified programming interface for microRNA data resources.

Anders Jacobsen1, Anders Krogh, Sakari Kauppinen

  • 1The Bioinformatics Centre, Department of biology, University of Copenhagen, 2200 Copenhagen N, Denmark. andersbj@binf.ku.dk

BMC Bioinformatics
|January 16, 2010
PubMed
Summary
This summary is machine-generated.

miRMaid is a new software platform that integrates microRNA (miRNA) data from miRBase and other resources into a unified web service. This tool helps researchers query complex miRNA information and facilitates the development of new bioinformatics tools.

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A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
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A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

Related Experiment Videos

Last Updated: Jun 17, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
09:29

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression.
  • The number of known miRNAs and associated data resources has grown significantly.
  • miRBase is the central repository for miRNA annotation, with over 10,000 precursors from 115 species.

Purpose of the Study:

  • To develop a software framework for integrating diverse miRNA data resources.
  • To provide a uniform web service interface for accessing and querying miRNA information.
  • To facilitate computational analysis of complex miRNA-related questions.

Main Methods:

  • Development of the miRMaid software framework.
  • Integration of miRBase data and design to follow official releases.
  • Exposing miRBase data through interconnected web services.
  • Modular integration of third-party miRNA data resources via plugins.
  • Option for loose coupling with external miRNA data entities.

Main Results:

  • miRMaid provides a unified web service interface for miRNA data.
  • The framework supports integration of miRBase and independent miRNA resources.
  • miRMaid can be accessed as a public web service or installed locally.
  • The software is freely available under the LGPL open-source license.

Conclusions:

  • miRMaid unifies disparate miRNA data resources, including miRBase.
  • It empowers researchers to address complex computational questions involving miRNA data.
  • Serves as a foundational framework for developing new miRNA bioinformatics tools and data sources.