Time-programmed dual release formulation by multilayered drug-loaded nanofiber meshes

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nanotechnology

Background:

• Developing advanced drug carriers is crucial for effective combination therapies.
• Sequential administration of multiple drugs requires sophisticated delivery systems.
• Current formulations often lack precise temporal control over drug release.

Purpose of the Study:

• To design and fabricate a multilayered drug carrier for time-programmed dual drug release.
• To control drug release kinetics and duration by manipulating mesh morphology.
• To demonstrate the potential of this system for sequential chemotherapy.

Main Methods:

• Sequential electrospinning was used to create tetra-layered nanofiber meshes.
• Meshes were loaded with two different drugs in distinct layers.
• Morphological features (fiber diameter, mesh thickness) were optimized for release control.
• Barrier mesh thickness was adjusted to control the retardation period for the second drug.

Main Results:

• The multilayered nanofiber mesh successfully achieved time-programmed dual drug release in vitro.
• Drug release profiles were modulated by controlling fiber diameter and mesh thickness.
• The barrier mesh effectively controlled the release timing of the second drug.

Conclusions:

• The developed multilayered electrospun nanofiber mesh is a promising platform for timed dual drug delivery.
• This system offers a viable strategy for advanced multidrug combination therapy and sequential chemotherapy.
• The formulation facilitates regiospecific administration of different drugs at distinct times.