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Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety
Published on: November 11, 2022
A hierarchical model for the relationships between general and specific vulnerability factors and symptom levels of
Colin van der Heiden1, Kim Melchior, Peter Muris
1Outpatient Treatment Center PsyQ, Rotterdam, The Netherlands; Institute of Psychology, Erasmus University Rotterdam, The Netherlands. c.vanderheiden@psyq.nl
Abstract:
The present study examined a hierarchical model for the relationships between general and specific vulnerability factors and symptom manifestations of generalized anxiety disorder (GAD). A clinical sample of patients with GAD (N=137) completed a set of self-report questionnaires for measuring neuroticism, extraversion, intolerance of uncertainty, metacognitive beliefs, and symptoms of generalized anxiety (i.e., worry) and depression. A bootstrapping analysis yielded support for a model in which the relation between the general vulnerability factor of neuroticism and symptoms of GAD were mediated by the specific vulnerability factors of intolerance of uncertainty and negative metacognitions. Implications for the classification and treatment of GAD are discussed.
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