Related Experiment Video
Updated: Jun 17, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Orbital frontal cortex in treatment-naïve pediatric obsessive-compulsive disorder
Frank Macmaster1, Anvi Vora, Phillip Easter
1Department of Psychiatry & Behavioral Neurosciences, Wayne State University, Children's Hospital of Michigan, Detroit, MI 48201, USA.
None:
The orbital frontal cortex (OFC) has been implicated in obsessive-compulsive disorder (OCD). Participants comprised 28 treatment-naïve pediatric OCD patients and 21 controls, who were examined using magnetic resonance imaging. OCD patients had larger right but not left OFC white matter volume than controls. This is fresh evidence implicating white matter in OCD.
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