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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...

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Updated: Jun 17, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Neuroglobin expression in ischemic stroke.

Kunlin Jin, Ying Mao, Xiao Mao

    Stroke
    |January 16, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Ischemic stroke increases the expression of neuroglobin, a protein that protects neurons. This finding suggests neuroglobin may be a new therapeutic target for stroke treatment.

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    An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
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    A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
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    A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

    Published on: November 14, 2020

    Area of Science:

    • Neuroscience
    • Neurology
    • Molecular Biology

    Background:

    • Neuroglobin is a neuronal protein known for its neuroprotective properties against hypoxic-ischemic injury.
    • Ischemic stroke is a major cause of brain damage resulting from reduced blood flow.

    Purpose of the Study:

    • To investigate the expression levels of neuroglobin in the context of ischemic stroke.
    • To determine if neuroglobin is upregulated following ischemic brain injury.

    Main Methods:

    • Measurement of neuroglobin immunoreactivity in brain tissue samples.
    • Comparison of neuroglobin levels between control subjects and patients with ischemic stroke.

    Main Results:

    • Neuroglobin was detected in various brain regions.
    • Significantly increased expression of neuroglobin was observed in the cortical peri-infarct zone after ischemic stroke.

    Conclusions:

    • Ischemic stroke leads to an increase in the expression of the neuroprotective protein neuroglobin.
    • Neuroglobin emerges as a potential novel therapeutic target for stroke management and treatment.