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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

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Published on: December 6, 2016

Sleep-disordered breathing changes after kidney transplantation: a polysomnographic study.

Cassio J O Rodrigues¹, Odair Marson, Sonia M G P Togeiro

¹Nephrology Division, Federal University of São Paulo, Brazil. cjorodrigues@uol.com.br

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|January 16, 2010

Summary

Kidney transplantation improves sleep architecture in end-stage renal disease (ESRD) patients. However, it does not fully resolve sleep-disordered breathing (SDB), indicating further research is needed for SDB treatment in ESRD.

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Last Updated: Jun 17, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Area of Science:

Nephrology
Sleep Medicine
Transplantation Medicine

Background:

Sleep disorders, including sleep-disordered breathing (SDB), are prevalent in end-stage renal disease (ESRD) patients.
Conventional dialysis methods do not effectively treat SDB in ESRD.
SDB is linked to increased cardiovascular risk and mortality in ESRD patients.

Purpose of the Study:

To investigate the impact of kidney transplantation on sleep-disordered breathing (SDB) in patients with end-stage renal disease (ESRD).
To assess changes in sleep architecture and SDB parameters post-transplantation.

Main Methods:

A cohort of 34 non-diabetic ESRD patients was studied.
Clinical, laboratory, and polysomnographic data were collected before and after kidney transplantation.
Patients were categorized based on an apnoea-hypopnoea index (AHI) >or=5 to define SDB.

Main Results:

SDB was present in 26.5% of patients pre-transplantation and 21% post-transplantation.
No significant reduction in the mean apnoea-hypopnoea index (AHI) was observed post-transplantation (5.3 vs 3.1).
Kidney transplantation led to a significant improvement in overall sleep architecture.

Conclusions:

Kidney transplantation improves sleep architecture in ESRD patients.
Transplantation does not universally cure sleep-disordered breathing in all ESRD patients.
Further strategies may be necessary to fully address SDB in the post-transplant ESRD population.