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Published on: December 6, 2016
Sleep-disordered breathing changes after kidney transplantation: a polysomnographic study
Cassio J O Rodrigues1, Odair Marson, Sonia M G P Togeiro
1Nephrology Division, Federal University of São Paulo, Brazil. cjorodrigues@uol.com.br
Summary
Kidney transplantation improves sleep architecture in end-stage renal disease (ESRD) patients. However, it does not fully resolve sleep-disordered breathing (SDB), indicating further research is needed for SDB treatment in ESRD.
Area of Science:
- Nephrology
- Sleep Medicine
- Transplantation Medicine
Background:
- Sleep disorders, including sleep-disordered breathing (SDB), are prevalent in end-stage renal disease (ESRD) patients.
- Conventional dialysis methods do not effectively treat SDB in ESRD.
- SDB is linked to increased cardiovascular risk and mortality in ESRD patients.
Purpose of the Study:
- To investigate the impact of kidney transplantation on sleep-disordered breathing (SDB) in patients with end-stage renal disease (ESRD).
- To assess changes in sleep architecture and SDB parameters post-transplantation.
Main Methods:
- A cohort of 34 non-diabetic ESRD patients was studied.
- Clinical, laboratory, and polysomnographic data were collected before and after kidney transplantation.
- Patients were categorized based on an apnoea-hypopnoea index (AHI) >or=5 to define SDB.
Main Results:
- SDB was present in 26.5% of patients pre-transplantation and 21% post-transplantation.
- No significant reduction in the mean apnoea-hypopnoea index (AHI) was observed post-transplantation (5.3 vs 3.1).
- Kidney transplantation led to a significant improvement in overall sleep architecture.
Conclusions:
- Kidney transplantation improves sleep architecture in ESRD patients.
- Transplantation does not universally cure sleep-disordered breathing in all ESRD patients.
- Further strategies may be necessary to fully address SDB in the post-transplant ESRD population.
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