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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 17, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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Published on: September 15, 2018

Chimeric animal models in human stem cell biology.

Joel C Glover1, Jean-Luc Boulland, Gabor Halasi

  • 1Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Blindern 0317 Oslo, Norway. joel.glover@medisin.uio.no

ILAR Journal
|January 16, 2010
PubMed
Summary

Preclinical animal models are crucial for human stem cell research in regenerative medicine. This review addresses challenges in using these models, focusing on imaging and tracking techniques for better in vivo assessment.

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Last Updated: Jun 17, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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Published on: September 15, 2018

Tissue Targeted Embryonic Chimeras: Zebrafish Gastrula Cell Transplantation
18:57

Tissue Targeted Embryonic Chimeras: Zebrafish Gastrula Cell Transplantation

Published on: September 11, 2009

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Preclinical Research

Background:

  • Clinical applications of stem cells rely heavily on animal models for preclinical evaluation.
  • Key challenges include experimental standardization, immunological barriers, and cell tracking.

Purpose of the Study:

  • To review critical issues and challenges in using animal models for human stem cell research.
  • To evaluate in vivo imaging modalities for tracking stem cells dynamically.
  • To provide an overview of commonly used animal models for xenotypic transplantation.

Main Methods:

  • Literature review focusing on experimental standardization, immunological barriers, cell survival, cell fusion, and in vivo imaging.
  • Comparative analysis of various imaging modalities (e.g., MRI, PET, fluorescence imaging).
  • Examination of animal models including rodents, ungulates, nonhuman primates, and chicken embryos.

Main Results:

  • Significant challenges exist in standardizing experiments and overcoming immunological barriers in xenotransplantation.
  • In vivo imaging techniques offer dynamic assessment of stem cell behavior but have limitations.
  • Different animal models present unique advantages and disadvantages for specific human stem cell applications.

Conclusions:

  • Advancements in genetic manipulation, cell delivery, and imaging will enhance the utility of human/animal chimeric models.
  • Optimizing animal models is essential for the successful clinical translation of stem cell therapies.
  • Further development of sophisticated imaging and model systems is needed for dynamic stem cell assessment.