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Hormonal steroids act as tumour promoters by modulating oncogene expression
1Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece.
Journal of Cancer Research and Clinical Oncology
|January 1, 1991
Summary
Steroid hormones may promote tumors by altering oncogene expression. This occurs when carcinogens modify genes, making them susceptible to abnormal hormonal control, a key step in carcinogenesis.
Area of Science:
- Oncology
- Molecular Biology
- Endocrinology
Background:
- Steroid hormones play a role in cell transformation and tumor formation.
- Oncogenes are crucial in the process of cell transformation.
- Carcinogenesis is generally understood as a multi-stage process.