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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

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Published on: February 23, 2014

Invasive pneumococcal disease following treatment for choroid plexus carcinoma

Mette Jorgensen1, Jessica Bate, Sylvia Gatscher

  • 1Department of Haematology/Oncology, Great Ormond Street Hospital, London WC1N 3JH, UK.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|January 16, 2010
PubMed

Insights

A child treated for choroid plexus carcinoma developed a Streptococcus pneumoniae subdural empyema post-chemotherapy. This case underscores the need for pneumococcal vaccination guidelines after cancer treatment.

Area of Science:

  • Pediatric Oncology
  • Infectious Diseases
  • Neuroscience

Background:

  • A 13-month-old child underwent treatment for choroid plexus carcinoma, including embolization, surgery, and chemotherapy.
  • The patient's medical history was complicated by chronic bilateral subdural collections.

Observation:

  • Four months after completing cancer treatment, the child developed a subdural empyema.
  • The empyema was caused by Streptococcus pneumoniae, specifically serotype 6A.

Findings:

  • The case presents a rare complication of Streptococcus pneumoniae infection in a pediatric patient previously treated for brain cancer.
  • The development of empyema occurred in the context of pre-existing subdural collections.

Implications:

  • This case highlights critical questions regarding the efficacy and timing of pneumococcal immunization in pediatric cancer survivors post-chemotherapy.
  • There is an urgent need for evidence-based guidelines to ensure optimal patient care and prevent such infections.
Abstract

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