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Class I MHC molecules as probes of membrane patchiness: from biophysical measurements to modulation of immune

Michael Edidin1

  • 1Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. edidin@jhu.edu

Immunologic Research
|January 16, 2010
PubMed

Here I summarize decades of work using the biophysics of class I MHC molecules to probe the patchiness and heterogeneity of cell surfaces. This program began as a study of membranes generally. MHC molecules were a convenient probe. However, in recent years, it has become clear that the lateral distribution, clustering, of class I MHC molecules in the membrane affects their recognition by effector CTL. This offers the possibility of enhancing or reducing T-cell recognition of targets by altering the clustering of their membrane proteins.

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