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Optimal designs for two-arm, phase II clinical trial design with multiple constraints

Matthew S Mayo1, Jonathan D Mahnken, Seng-Jaw Soong

  • 1Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. mmayo@kumc.edu

Journal of Biopharmaceutical Statistics
|January 16, 2010
PubMed
Summary

This study introduces a new clinical trial design for multi-stage Phase II trials. It incorporates a control arm for better treatment comparison and response rate estimation, improving trial efficiency.

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