Related Experiment Video
Updated: Jun 17, 2026
Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
Published on: August 12, 2019
[Effects of C-reactive protein on chemotaxis ability of monocytes in vitro]
1State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the effects of C-reactive protein (CRP) on monocytes chemotaxis ability in vitro.
Methods:
Transwell chemotaxis assay was used to evaluate the changes of chemotactic ability of THP-1 monocytes in each group treated with CRP in different concentration.
Results:
CRP increased the number of attracted monocytes in response to MCP-1 (monocyte chemoattractant protein-1). When treated with CRP concentration at 2 microg x mL(-1), the number of chemotactic monocytes increased (P < 0.05). The number of attracted monocytes increased as CRP concentration was elevated (P < 0.05).
Conclusion:
CRP can increase chemotactic ability of THP-1 monocytes in concentration dependent manner.
