Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

RIBOFLAVIN deficiency in rheumatic Diseases: A call for clinical trials.

Rheumatology and immunology research·2026

Same author

Polyarteritis nodosa and antiphospholipid syndrome: a systematic review of a rare and challenging overlap between vasculitis and thrombotic vasculopathy.

Clinical rheumatology·2026

Same author

Intermittent hydrarthrosis (periodic synoviosis): A narrative review.

Autoimmunity reviews·2026

Same author

Antidotes in Homeopathy: Classical Doctrine, Clinical Relevance and Scientific Re-interpretation.

Homeopathy : the journal of the Faculty of Homeopathy·2026

Same author

Multiple Tophi and Tophus Aspirate in a Gouty Patient.

The Israel Medical Association journal : IMAJ·2026

Same author

Hydroxychloroquine as an Adjunct Therapy for Secondary Thrombosis Prevention in Primary Antiphospholipid Syndrome: A Systematic Review and Meta-analysis.

Rheumatology and therapy·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Hematopoietic cell transplants in autoimmunity.

Jozélio Freire de Carvalho¹, Rosa Maria Rodrigues Pereira, M Eric Gershwin

¹Rheumatology Division, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. jotafc@gmail.com

The Israel Medical Association Journal : IMAJ

|January 19, 2010

Summary

Hematopoietic stem cell transplantation shows promise for treating autoimmune diseases, but challenges in efficacy, safety, and delivery remain. Integrating basic research into clinical trials is crucial for advancing this novel therapeutic approach.

More Related Videos

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

Related Experiment Videos

Last Updated: Jun 17, 2026

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

Area of Science:

Immunology
Hematology

Background:

Autoimmune diseases affect approximately 1 in 31 individuals.
Clinical management of autoimmunity spans multiple pediatric and internal medicine subspecialties.
Etiology and therapy are key considerations in autoimmune disease analysis.

Purpose of the Study:

To review the potential of hematopoietic stem cell transplantation (HSCT) as a therapeutic strategy for autoimmune diseases.
To discuss the challenges and promise associated with HSCT in managing autoimmunity.
To highlight the importance of integrating basic research into clinical therapeutic trials.

Main Methods:

Review of current literature and clinical perspectives on HSCT for autoimmune conditions.
Analysis of factors influencing the efficacy, safety, and delivery of HSCT.
Emphasis on the gap between basic research and clinical application.

Main Results:

HSCT is a promising but complex approach for autoimmune disease management.
Significant challenges exist regarding economics, healthcare delivery, efficacy, and safety of HSCT.
There is a critical need to bridge basic research findings with clinical trial design.

Conclusions:

Hematopoietic stem cell transplantation offers a novel therapeutic avenue for autoimmune diseases.
Further research and careful consideration of practical challenges are necessary for successful implementation.
Integrating fundamental scientific discoveries into clinical practice is essential for therapeutic advancement.