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Synthesis of (+/-)-bistellettadine A

Min Yu1, Susan S Pochapsky, Barry B Snider

  • 1Department of Chemistry MS 015, Brandeis University, Waltham, Massachusetts 02454-9110, USA.

Organic Letters
|January 19, 2010
PubMed
Abstract

None:

Esterification of the trienoic acid with o-xylylene dibromide gave the bis ester that underwent a templated Diels-Alder reaction to afford the macrodiolide stereospecifically in a single step. The synthesis of bistellettadine A was completed in four steps by hydrolysis and side chain elaboration.

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