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Correction: Zsengellér et al. Mitigating Oxidative Stress and Anti-Angiogenic State in an In Vitro Model of Preeclampsia by HY-12, an Organofluorine Hydrazone Antioxidant. <i>Curr. Issues Mol. Biol.</i> 2025, <i>47</i>, 680.

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Related Experiment Video

Updated: Jun 17, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Pathogenesis of preeclampsia.

Brett C Young¹, Richard J Levine, S Ananth Karumanchi

¹Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

Annual Review of Pathology

|January 19, 2010

Summary

Preeclampsia, a pregnancy complication affecting 3-5% of women, involves high blood pressure and protein in urine. Understanding placental antiangiogenic factors offers hope for early detection and treatment.

Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine
Pathophysiology

Background:

Preeclampsia affects 3-5% of pregnancies, causing hypertension and proteinuria after 20 weeks gestation.
It is a major cause of maternal and neonatal morbidity and mortality.
Current management relies solely on placental delivery.

Purpose of the Study:

To review recent advances in understanding preeclampsia pathogenesis.
To highlight the role of placental antiangiogenic factors.
To explore potential diagnostic and therapeutic implications.

Main Methods:

Review of recent scientific discoveries and literature.
Analysis of the role of antiangiogenic factors in endothelial disruption.
Correlation of angiogenic imbalance with clinical manifestations of preeclampsia.

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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

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Published on: November 20, 2015

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Last Updated: Jun 17, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Main Results:

Upregulation of placental antiangiogenic factors disrupts maternal endothelium.
This imbalance contributes to hypertension, proteinuria, and HELLP syndrome.
The precise regulation of these factors in the placenta remains undetermined.

Conclusions:

Recent discoveries illuminate the pathogenesis of preeclampsia.
Upregulated antiangiogenic factors present potential biomarkers for prediction and diagnosis.
These factors offer promising targets for future therapeutic interventions.