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The rationale for identifying clinical predictors modifiable by tissue engineering for translational models.
Kurt P Spindler1, Warren R Dunn
1Department of Orthopaedics, Vanderbilt University, Vanderbilt Sports Medicine, Nashville, Tennessee 37232-8774, USA. kurt.spindler@vanderbilt.edu
Tissue Engineering. Part B, Reviews
|January 19, 2010
Summary
Functional tissue engineering (TE) can improve patient outcomes by addressing predictors like meniscus tears after anterior cruciate ligament injury. This approach bridges clinical needs with laboratory solutions for better musculoskeletal health.
Area of Science:
- Biomedical Engineering
- Orthopedics
- Regenerative Medicine
Background:
- Musculoskeletal tissue engineering (TE) requires a strong link between clinical research and laboratory evaluation.
- Identifying clinically relevant predictors amenable to TE is crucial for improving patient outcomes.
Purpose of the Study:
- To propose a "bedside-to-bench" model for functional TE to enhance clinical outcomes.
- To highlight the potential of TE in addressing meniscus injury as a predictor of osteoarthritis after anterior cruciate ligament (ACL) injury.
Main Methods:
- Developing TE solutions in the laboratory.
- Testing TE efficacy and safety in translational models before clinical trials.
- Focusing on preserving meniscus function as a key clinical outcome.
Main Results:
- Meniscus tears, occurring in ~50% of ACL injuries, are proven predictors of osteoarthritis.
- TE offers potential solutions for meniscus repair or replacement, addressing a key clinical need.
Conclusions:
- A "bedside-to-bench" approach is essential for translating TE advancements into clinical practice.
- Functional TE targeting meniscus preservation can mitigate osteoarthritis development post-ACL injury.
