Tissue reaction to implantation of collagen film

A new modified collagen film was investigated to evaluate the tissue reaction and absorption time (a) after implantation in rabbit muscle, and (b) in a human model where collagen was implanted in the prostatic cavity during operation. Clinical follow-up by cystoscopy and biopsy was made one week postoperatively. The animal results showed that for 6 weeks after implantation there was a cellular reaction associated with phagocytosis of the collagen film. Then a scar was formed, similar to that in the controls. The human results showed a similar tissue reaction and no adverse effects from the collagen film.