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Four cases of distinctive meningiomas with Zellballen growth pattern
Yingchun Dong1, Xiaojun Zhou, Bo Wu
1Department of Pathology, Clinical School of Medical College of Nanjing University/Nanjing Jinling Hospital, Nanjing, China.
Abstract:
Meningiomas are attributed to those tumours with slow-growing pattern occurring predominantly in middle-aged or elderly patients. Fifteen histological variants have been described based on the variable histomorphological features. Herein we report four cases with specific Zellballen growth pattern, giving the tumours a 'paraganglioma-like' general aspect. The diagnosis of meningiomas was confirmed by immunohistochemical and ultrastructural findings. Histopathologists should be aware of this specific morphology which can lead to misdiagnosis.
Insights
Meningiomas, slow-growing brain tumors, can exhibit a rare Zellballen pattern. This morphology mimics paragangliomas, potentially leading to misdiagnosis by pathologists.
Area of Science:
- Neuropathology
- Oncology
Background:
- Meningiomas are common primary tumors of the central nervous system.
- They are typically slow-growing and occur in adults.
- Fifteen histological variants of meningioma are recognized.
Observation:
- This report details four meningioma cases exhibiting a distinct Zellballen growth pattern.
- This pattern imparts a 'paraganglioma-like' appearance to the tumors.
- The Zellballen morphology is not a commonly described feature of meningiomas.
Findings:
- The diagnosis of meningioma was confirmed using immunohistochemical markers and ultrastructural analysis.
- Histological examination revealed the characteristic Zellballen (small nests) growth pattern.
- The Zellballen pattern in these cases resembled that seen in paragangliomas.
Implications:
- Pathologists must recognize this specific Zellballen morphology in meningiomas.
- Awareness of this pattern is crucial to avoid potential misdiagnosis.
- This finding expands the understanding of meningioma histopathological diversity.
