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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Fluoride content of powdered infant formula meets Australian Food Safety Standards
Helen Clifford1, Henry Olszowy, Megan Young
1Queensland Health, Southport, QLD 4215. helen_clifford@health.qld.gov.au
Insights
Infant formula powders in Australia contain less fluoride than a decade ago. While soy formulas have higher fluoride than milk-based ones, both remain within safe national standards for infant consumption.
Area of Science:
- Environmental Health
- Pediatric Nutrition
- Analytical Chemistry
Background:
- Fluoride intake in infants is a critical factor in dental health and overall development.
- Previous studies in Australia (1996) established baseline fluoride levels in infant formula.
- Understanding current fluoride content is essential for assessing infant exposure and potential health impacts.
Purpose of the Study:
- To determine the fluoride concentration in powdered infant formulas available in Brisbane, Australia (2006/07).
- To compare these levels with data from 10 years prior.
- To estimate the daily fluoride intake for infants aged 0-12 months based on formula type and water fluoridation.
Main Methods:
- Infant formula powder samples were collected from major Brisbane retailers.
- Fluoride levels were quantified using a modified micro-diffusion method with ion-selective electrode detection.
- Fluoride content was analyzed pre- and post-reconstitution, and daily intake was calculated based on age and water fluoride levels.
Main Results:
- Powdered infant formulas averaged 0.49 microg F/g (range 0.24-0.92 microg F/g).
- Reconstituted formula (with 0 mg/L fluoride water) averaged 7.09 microg F/100mL (range 3.367-22.72 microg F/100mL).
- Estimated daily fluoride intake varied significantly, from 0.0039 mg/kg/day (milk-based, non-fluoridated water) to 0.1735 mg/kg/day (soy-based, fluoridated water).
Conclusions:
- Current infant formula powders contain lower fluoride levels compared to Australian data from 1996.
- Milk-based formulas contribute minimal fluoride to infant diets.
- Soy-based formulas contain more fluoride than milk-based, but levels are compliant with national food standards.
Objectives:
To identify the fluoride content of powdered formula for infants 0-12 months in products available from Brisbane stores in 2006/07 and compare this with the fluoride content of infant formula products available in Australia 10 years earlier.
Methods:
A range of available infant formula powders were collected from major supermarkets and chemists in Brisbane, Queensland. The fluoride levels in infant formula powder samples were determined using a modification of the micro-diffusion method of Silva and Reynolds(1) utilising perchloric acid and silver sulphate and measured with an ion selective (fluoride) electrode/meter. Fluoride content both prior to and after reconstitution, as well as estimated daily intake according to age was calculated.
Results:
Formula samples contained an average of 0.49 microg F/g of powder (range 0.24-0.92 microg F/g). After reconstitution with water containing 0 mg/L fluoride, the fluoride content averaged 7.09 microg F/100mL (range 3.367-22.72 microg F/100mL). Estimated infant fluoride intakes ranged from 0.0039 mg/kg/day for a 6-12 month old infant when reconstituting milk-based formula with non-fluoridated water (0 mg/L), to 0.1735 mg/kg/day for a 0-3 month old infant when reconstituting soy-based formula with fluoridated water (1.0 mg/L).
Conclusions:
Infant formula powders contain lower levels of fluoride than previously found in Australia in 1996.
Implications:
This confirms that infants consume only a small amount of fluoride from milk-based powdered infant formula. Although soy-based infant formulas contain more fluoride than milk-based products, the levels still comply with national food standards.
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