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A randomized trial of propofol consumption and recovery profile with BIS-guided anesthesia compared to standard

Neerja Bhardwaj1, Sandhya Yaddanapudi

  • 1Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India. neerja.bhardwaj@gmail.com

Paediatric Anaesthesia
|January 19, 2010
PubMed

Insights

Bispectral index (BIS) monitoring did not reduce propofol use or improve anesthesia recovery in children. This study found no significant differences in propofol consumption or recovery times compared to standard practice.

Area of Science:

  • Anesthesiology
  • Pediatric Anesthesia
  • Monitoring

Background:

  • Bispectral index (BIS) monitoring is used to guide propofol administration in adults, reducing requirements and improving recovery.
  • Evidence for the utility of anesthesia depth monitors in children remains mixed, necessitating further investigation.

Purpose of the Study:

  • To assess the impact of BIS monitoring on propofol consumption and anesthesia recovery in pediatric patients.
  • To compare BIS-guided propofol administration with standard clinical practice in children aged 2-12 years.

Main Methods:

  • A prospective randomized study involving 50 pediatric patients (2-12 years) assigned to either standard practice (SP) or BIS monitoring groups.
  • Propofol infusion rates were adjusted based on systolic blood pressure (SP group) or BIS values (45-60) in the BIS group.
  • Propofol consumption and recovery metrics (eye opening, extubation, response to commands, Steward score) were recorded.

Main Results:

  • No significant difference was observed in mean propofol consumption between the BIS and SP groups (232.6 vs. 250.8 mg).
  • Intraoperative hemodynamics and BIS values were comparable across both groups.
  • Recovery times, including eye opening, extubation, and response to commands, did not differ significantly between the groups.

Conclusions:

  • Bispectral index (BIS)-guided propofol administration offers no discernible advantage in reducing anesthetic consumption or enhancing recovery in pediatric patients compared to standard anesthetic practices.
Abstract

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