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Updated: Jun 17, 2026

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice
Published on: January 7, 2019
[Association between monoamine oxidase A gene and major depression in Chinese Han population]
Jie-xu Zhang1, Yan-bo Chen, Ke-rang Zhang
1National Laboratory of Medical Molecular Biology, Institute of National Laboratory of Medical Molecular Biology, Beijing 100005, China.
Objective:
To explore the association between monoamine oxidase A (MAOA) variable number tandem repeat (VNTR) polymorphism and major depression in Chinese Han population.
Methods:
Polymerase chain reaction was used to genotype MAOA VNTR polymorphism. A total of 512 major depression patients and 566 normal controls were recruited in our study. These patients were also assessed using the 14-item Hamilton anxiety scale. RESULTS The allele frequency of MAOA VNTR was not significantly different between the male/female major depression patients and the normal controls. Compared with the normal controls, MAOA VNTR genotype was significantly more frequent in female major depression patients (P=0.002), but not in male patients (P=0.17). MAOA VNTR-L carrier was also associated with "fear" symptom in female patients (P=0.0056).
Conclusion:
MAOA gene is associated with the major depression in Chinese Han population, especially among female patients.
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