Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Cellular Adaptation I: Introduction and Atrophy

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Presenilin-1 controls glycolysis and identity of pancreatic beta cells.

Communications biology·2026

Same author

Do metabolic fluxes change with age?

Trends in endocrinology and metabolism: TEM·2026

Same author

Antifungal peptides: From modes of action to synergistic and immunologic potential.

Cell stress·2026

Same author

The lichen secondary metabolite lichesterinic acid exhibits antibiofilm activity against fungal pathogens.

Frontiers in cellular and infection microbiology·2026

Same author

The geroprotective potential of chalcones.

Nature communications·2025

Same author

Sugar accelerates chronological aging in yeast via ceramides.

Cell stress·2025

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

Ageing and eating.

Patrick Rockenfeller¹, Frank Madeo

¹University of Graz, Institute for Molecular Biology, Humboldtstrasse 50, 8010 Graz, Austria.

Biochimica Et Biophysica Acta

|January 19, 2010

Summary

This summary is machine-generated.

Exploring the link between diet and aging, this study uses yeast models to uncover molecular pathways. This research aims to differentiate between correlation and causation in how nutrition impacts lifespan and age-related diseases.

Related Experiment Videos

Last Updated: Jun 17, 2026

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

Area of Science:

Gerontology and molecular biology.
Nutritional science and disease mechanisms.

Background:

Epidemiological studies suggest lifestyle factors like diet and exercise influence human lifespan and age-related diseases.
Obesity is a growing public health concern with poorly understood molecular mechanisms driving organ degeneration and mortality.
Nutrient-related adverse health effects, including accelerated aging, can stem from high-fat/sugar diets, excessive alcohol, and smoking.

Purpose of the Study:

To investigate the complex relationship between dietary intake and the aging process.
To identify the molecular pathways linking nutrition to aging and age-associated diseases.
To utilize yeast as a model organism to distinguish correlative from causative effects of diet on aging.

Main Methods:

Review of epidemiological data on longevity and disease prevention.
Analysis of molecular mechanisms underlying obesity-related health issues.
Proposed use of yeast (Saccharomyces cerevisiae) as a model system for aging research due to conserved pathways and genetic tractability.

Main Results:

Existing studies show correlations between certain diets, lifestyle choices, and longevity, but lack causative evidence.
The molecular basis for obesity-induced organ damage and premature death remains largely unknown.
Yeast's conserved aging pathways and genetic manipulability offer a powerful tool to dissect nutrition-aging interdependencies.

Conclusions:

Understanding the causative molecular links between diet and aging is crucial for addressing public health challenges like obesity.
Yeast provides a tractable model to differentiate between correlative and causative dietary effects on aging.
Further research in yeast can elucidate pathways relevant to human aging and age-related diseases.