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Fibrin based drug delivery systems.

R I Senderoff1, M T Sheu, T D Sokoloski

  • 1Ohio State University, College of Pharmacy, Columbus.

Journal of Parenteral Science and Technology : a Publication of the Parenteral Drug Association
|January 1, 1991
PubMed
Summary

Fibrinogen and thrombin form a fibrin matrix for drug delivery. Researchers explored microparticles, coated particulates, and implantable sheets for sustained release of small and large molecules.

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Area of Science:

  • Biochemistry
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Fibrinogen is the natural substrate for thrombin in the blood coagulation cascade.
  • The conversion of fibrinogen to fibrin forms a polymerizing matrix.
  • This natural process offers potential for biodegradable drug delivery systems.

Purpose of the Study:

  • To explore the use of fibrin-based materials for sustained drug delivery.
  • To evaluate three distinct fibrin-based drug delivery systems.
  • To assess the release kinetics of small and large molecular weight substances.

Main Methods:

  • Investigated fibrin microparticles produced via emulsion with entrapped drug.
  • Examined fibrin-coated drug particulates formed by adsorbing fibrinogen onto drug particles before thrombin addition.
  • Developed fibrin sheets by casting with entrapped drug for potential implant applications.

Main Results:

  • Fibrin microparticles, fibrin-coated drug particulates, and fibrin sheets were successfully fabricated.
  • The drug release behavior from these systems was evaluated for both small and large molecules.
  • The study demonstrated the potential of these fibrin matrices for controlled substance release.

Conclusions:

  • Fibrin-based materials offer versatile platforms for sustained drug delivery.
  • The evaluated systems show promise for controlled release of diverse molecular weights.
  • Further research into fibrin biomaterials can advance drug delivery technologies.

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