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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Microarray blood testing: Pros & cons.

Juraj Petrik1

  • 1Scottish National Blood Transfusion Service, TTI Department, 21 Ellen's Glen Road, EH17 7QT Edinburgh, UK. juraj.petrik@nhs.net

Biologicals : Journal of the International Association of Biological Standardization
|January 19, 2010
PubMed
Summary
This summary is machine-generated.

Blood donation screening faces increasing targets for blood group antigens and infectious pathogens. Advanced multiplexing techniques and new testing platforms are crucial for future blood safety.

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Area of Science:

  • Transfusion Medicine
  • Infectious Disease Surveillance
  • Biotechnology

Background:

  • Blood donation screening requires a growing number of assays for blood grouping and pathogen detection.
  • Emerging and re-emerging infectious agents pose an increasing threat to blood safety due to global factors.
  • Current testing limitations necessitate broader screening for blood group antigens, alloantibodies, and pathogens.

Purpose of the Study:

  • To address the expanding scope of targets in blood donation screening.
  • To explore advanced technologies for simultaneous detection of multiple analytes.
  • To discuss future strategies for enhancing blood safety through improved testing algorithms.

Main Methods:

  • Review of current blood donation screening practices.
  • Evaluation of multiplexing techniques like microarrays for high-throughput testing.
  • Analysis of potential new targets including emerging viruses and prions.
  • Consideration of next-generation testing platforms.

Main Results:

  • Multiplexing technologies offer a promising solution for increasing testing targets.
  • Sensitivity improvements are needed for some microarray-based assays.
  • Several candidate infectious agents (e.g., Dengue, Chikungunya, Hepatitis E, variant CJD) require consideration for future screening.
  • Development of integrated platforms for comprehensive screening is underway.

Conclusions:

  • Future blood donation screening will likely integrate multiplexing techniques with existing assays.
  • Next-generation platforms are being developed to meet the growing demands for blood safety.
  • Proactive adaptation of screening protocols is essential to mitigate risks from novel pathogens and alloantibodies.