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Related Concept Videos

Paracrine Signaling01:21

Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
Paracrine Signaling01:21

Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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A Matrigel-Based Tube Formation Assay to Assess the Vasculogenic Activity of Tumor Cells
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A Matrigel-Based Tube Formation Assay to Assess the Vasculogenic Activity of Tumor Cells

Published on: September 7, 2011

Signalling pathways in vasculogenic mimicry.

Yvette W J Paulis1, Patricia M M B Soetekouw, Henk M W Verheul

  • 1Department of Internal Medicine, Division of Medical Oncology, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Center, Maastricht, The Netherlands.

Biochimica Et Biophysica Acta
|January 19, 2010
PubMed
Summary

Solid tumors need blood supply, and besides sprouting angiogenesis, tumor cells can form vessel-like structures through vasculogenic mimicry (VM). This review explores VM

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Area of Science:

  • Oncology and Cancer Biology
  • Vascular Biology
  • Tumor Microenvironment

Background:

  • Solid tumor growth relies on neovascularization.
  • Sprouting angiogenesis was historically considered the sole mechanism for tumor vascularization.
  • Emerging research reveals alternative vascularization strategies, including vasculogenic mimicry (VM).

Purpose of the Study:

  • To review signaling molecules and cascades involved in vasculogenic mimicry (VM).
  • To discuss the role and presence of VM in various cancer research contexts.
  • To examine the clinical significance of VM, particularly concerning anti-angiogenesis therapies.

Main Methods:

  • Literature review focusing on signaling pathways in VM.
  • Analysis of studies reporting VM occurrence across different tumor types.
  • Evaluation of clinical data linking VM to prognosis and treatment response.

Main Results:

  • Vasculogenic mimicry (VM) is a process where aggressive tumor cells create vessel-like networks.
  • VM is observed in various aggressive cancers and correlates with poor patient prognosis.
  • Specific signaling pathways driving VM are being elucidated, offering potential therapeutic targets.

Conclusions:

  • Vasculogenic mimicry (VM) represents a significant, non-angiogenic pathway for tumor vascularization.
  • Understanding VM mechanisms is crucial for developing effective anti-cancer strategies.
  • VM's clinical significance warrants further investigation for targeted therapeutic interventions.