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09:39
Mapping Dysfunctional Protein-Protein Interactions in Disease
Published on: October 24, 2025
The egg white and yolk interactomes as gleaned from extensive proteomic data
Angelo D'Alessandro1, Pier Giorgio Righetti, Elisa Fasoli
1Department of Environmental Sciences, University of Tuscia, Viterbo, Italy.
Journal of Proteomics
|January 19, 2010
Summary
Chicken egg yolk and white proteomics reveal key proteins involved in cell development and antimicrobial responses. SERPINB3 (Squamous Cell Carcinoma Antigen 1) is highlighted for its roles in both egg components.
Area of Science:
- Proteomics
- Biochemistry
- Molecular Biology
Background:
- Chicken egg yolk and white are complex biological fluids.
- Previous studies have mapped their protein content.
- A unified view of these proteomes is needed.
Purpose of the Study:
- To consolidate and analyze existing literature data on chicken egg yolk and white proteomes.
- To identify key proteins and pathways involved in egg functions.
- To provide a unified perspective on egg proteomics.
Main Methods:
- Literature data compilation and regrouping.
- Network and pathway analyses.
- Exclusion of redundant proteins and maintenance of isoforms.
Main Results:
- Identified 260 gene products in egg yolk and 148 in egg white.
- Revealed roles for proteins in cell development, proliferation, migration, cell-cell interaction, and hematological system development.
- Highlighted histones, lysozyme, vitamin-binding proteins, and SERPINB3 (ovalbumin Y/SCCA1) for antimicrobial responses.
Conclusions:
- Despite potential data incompleteness, valuable insights into egg proteomes were obtained.
- SERPINB3 plays a significant role in both egg yolk and white, particularly in inflammation and coagulation pathways.
- Further research is needed to correlate these findings with the role of egg yolk proteins in counteracting blood coagulation.
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