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Updated: Jun 17, 2026
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
Published on: December 28, 2013
Evaluation of the accumulation of (11)C-methionine with standardized uptake value in the normal brain
Takehiro Uda1, Naohiro Tsuyuguchi, Yuzo Terakawa
1Department of Neurosurgery, Graduate School of Medicine, Osaka City University, Abeno-ku, Osaka, Japan. uda@med.osaka-cu.ac.jp
Unlabelled:
The aim of this study was to determine the normal l-[methyl-(11)C]-methionine ((11)C-methionine) uptake and the extent of variation using standardized uptake value (SUV).
Methods:
Five healthy volunteers and 58 adult patients with normal (11)C-methionine uptake were included in the interindividual analysis and 22 patients in the intraindividual analysis. SUVs in different brain regions, age-associated changes, correlation between 2 correction methods (for body weight [w-SUV] or body surface area [s-SUV]), and intraindividual reproducibility were examined.
Results:
w-SUVs were statistically different between the brain regions. The frontal or parietal cortex showed lower coefficients of variation than did the cerebellum or brain stem. There was no significant age-associated change. w-SUVs showed lower coefficients of variation in interindividual analysis and lower symmetric percentage change in intraindividual reproducibility than did s-SUVs.
Conclusion:
SUVs in the normal brain show inter- and intraindividual variation, and our proposed normal w-SUVs represent an important reference value.
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