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The heat shock protein profile in children with chronic kidney disease

Kinga Musial1, Krystyna Szprynger, Maria Szczepańska

  • 1Department of Pediatric Nephrology, Medical University, Wroclaw, Poland.

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|January 19, 2010
PubMed

Insights

Children with chronic kidney disease (CKD) show altered heat shock proteins (HSPs) and antibodies, suggesting disturbed stress responses and potential roles as atherosclerosis markers.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Research
  • Immunology

Background:

  • Chronic kidney disease (CKD) in children is linked to inflammation, lipid disorders, and endothelial dysfunction, increasing atherosclerosis risk.
  • Elevated heat shock proteins (HSPs) and anti-HSP antibodies are associated with atherosclerosis in adults, but their role in pediatric CKD is unexplored.

Purpose of the Study:

  • To investigate the profile of HSPs and their antibodies in children with CKD.
  • To assess the potential role of HSPs as atherosclerosis markers in pediatric CKD patients.

Main Methods:

  • Studied 37 children with conservative CKD, 19 on automated peritoneal dialysis (APD), and 15 healthy controls.
  • Measured serum concentrations of HSP-60, HSP-70, HSP-90alpha, anti-HSP-60, anti-HSP-70, sE-selectin, IL-4, and hs-CRP.
  • Assessed serum lipid profiles (total cholesterol, HDL, LDL, triglycerides).

Main Results:

  • HSP-90alpha, anti-HSP-60, and sE-selectin were elevated in CKD and APD patients compared to controls.
  • Anti-HSP-70 levels were higher in CKD patients than controls; IL-4 was increased in all patient groups.
  • HSP-60 levels were decreased in CKD and APD children, while HSP-70 and hs-CRP were similar across groups.

Conclusions:

  • Altered HSP and anti-HSP concentrations suggest disturbed stress responses in pediatric CKD, not significantly worsened by APD.
  • Relationships between HSPs, lipids, and inflammation markers indicate HSPs may serve as atherosclerosis markers in children with CKD.
Abstract

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