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[Response to hepatitis B vaccine in infants with mother-to-child HCV infection]

Małgorzata Aniszewska1, Barbara Kowalik-Mikołajewska, Maria Pokorska-Lis

  • 1Klinika Chorób Zakaźnych Wieku Dzieciecego, Warszawski Uniwersytet Medyczny, Wojewódzki Szpital Zakaźny w Warszawie, 01-201 Warszawa. malgorzata.aniszewska@wum.edu.pl

Medycyna Wieku Rozwojowego
|January 19, 2010
PubMed

Insights

Hepatitis B vaccination in infants born to mothers with Hepatitis C virus (HCV) infection resulted in a weaker anti-HBs antibody response compared to uninfected infants. Seroconversion rates were lower in the HCV-infected group.

Area of Science:

  • Hepatology
  • Immunology
  • Pediatrics

Context:

  • Hepatitis C virus (HCV) infection poses risks to infants via mother-to-child transmission.
  • Hepatitis B virus (HBV) vaccination is crucial for preventing HBV infection, especially in high-risk populations.
  • Understanding vaccine response in vulnerable infant populations is essential for public health.

Purpose:

  • To evaluate the anti-HBs seroconversion rates following hepatitis B vaccination in infants with confirmed mother-to-child HCV infection.
  • To compare the immune response to the hepatitis B vaccine between infants infected with HCV and those without HCV infection.

Summary:

  • 105 infants born to HCV-infected mothers received the hepatitis B vaccine. 18 infants were confirmed HCV-infected (Group A), and 87 were HCV-uninfected (Group B).
  • Anti-HBs titers were measured post-vaccination. Overall seroconversion (>10 mIU/ml) was 88.6%.
  • Group A (HCV-infected) showed a lower seroconversion rate (73%) compared to Group B (92%, p=0.04).

Impact:

  • Infants with HCV infection exhibit a diminished response to the hepatitis B vaccine.
  • This finding highlights the need for potential monitoring or adjusted vaccination strategies in infants with HCV.
  • Ensuring adequate protection against HBV is critical for all infants, particularly those with co-existing infections.
Abstract

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