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Hepatitis C virus infection and kidney transplantation: a review for clinicians

Behzad Einollahi1, Seyed-Moayed Alavian

  • 1Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. einollahi@inu.ir

Iranian Journal of Kidney Diseases
|January 19, 2010
PubMed

Insights

Kidney transplant recipients frequently have Hepatitis C virus (HCV) infection, a leading cause of chronic liver disease post-transplant. This review covers current information on managing HCV in kidney transplant patients.

Area of Science:

  • Nephrology
  • Hepatology
  • Transplantation

Background:

  • Hepatitis C virus (HCV) infection is common in kidney transplant recipients.
  • HCV is a major cause of chronic liver disease after kidney transplantation.
  • HCV infection impacts morbidity and mortality in dialysis patients.

Purpose of the Study:

  • To review current information on Hepatitis C virus in kidney transplant recipients.
  • To address key questions regarding HCV transplantation indications, evaluation, and outcomes.

Main Methods:

  • Literature review of pretransplant and posttransplant evaluations.
  • Analysis of complications, treatment, and prognosis for HCV-infected kidney transplant recipients.

Main Results:

  • Kidney transplantation may be a viable option for select HCV-infected patients after thorough evaluation.
  • Several critical questions remain regarding transplantation protocols and outcomes in this population.

Conclusions:

  • Management of HCV in kidney transplant recipients requires careful pre- and post-transplant assessment.
  • Further research is needed to optimize outcomes for HCV-infected kidney transplant recipients.

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