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Correlation between amputation of diabetic foot and nephropathy
Ozra Akha1, Zahra Kashi, Atieh Makhlough
1Department of Endocrinology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran. zr_akha@yahoo.com
Iranian Journal of Kidney Diseases
|January 19, 2010
Summary
Elevated serum creatinine levels in patients with diabetic foot are strongly linked to lower extremity amputations. Early detection and intervention are crucial for preventing amputations in this high-risk population.
Area of Science:
- Nephrology
- Diabetology
- Vascular Surgery
Background:
- Diabetic foot lesions are a significant cause of morbidity in patients with diabetes and chronic kidney disease.
- Understanding the relationship between kidney function and amputation risk is critical for patient outcomes.
Purpose of the Study:
- To investigate the association between kidney function indicators and the risk of lower extremity amputation in patients with diabetic foot.
- To identify predictive factors for amputation in diabetic foot patients.
Main Methods:
- Retrospective chart review of 244 diabetic foot patients admitted between 1996 and 2005.
- Analysis of clinical characteristics, urine protein excretion, and serum creatinine levels.
- Comparison of kidney function indicators between amputee and non-amputee groups.
Main Results:
- Amputation was performed in 27.0% of patients (66 out of 244).
- Amputees were significantly older than non-amputees (P < .001).
- Mean serum creatinine levels were significantly higher in amputees (1.78 mg/dL) compared to non-amputees (1.28 mg/dL) (P = .03).
Conclusions:
- Elevated serum creatinine levels are strongly associated with lower extremity amputations in diabetic foot patients.
- Intensified preventive measures are necessary for patients with diabetic foot and impaired kidney function.
- Monitoring kidney function is essential in managing diabetic foot complications.
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