Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental toxicity of valproic acid.

D Cotariu1, J L Zaidman

  • 1Department of Biochemical Pathology, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Zerifin, Israel.

Life Sciences
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum electrolyte and blood gas changes after intrathecal and intravenous bolus injections of magnesium sulphate. An experimental study in a rat model.

Anaesthesia·1997
Same author

Routine childhood screening for hyperlipidemia in Israel.

Israel journal of medical sciences·1996
Same author

Erythrocyte Na+, K+ and Ca2+, Mg(2+)-ATPase activities in hypertensives on angiotensin-converting enzyme inhibitors.

Clinical biochemistry·1996
Same author

Changes in red blood cell glutathione and glutathione-dependent enzymes on long-term treatment with captopril and enalapril.

Clinica chimica acta; international journal of clinical chemistry·1995
Same author

Comparison of serum C-reactive protein concentrations for laparoscopic versus open cholecystectomy.

Surgical endoscopy·1995
Same author

Red blood cell glutathione status in patients with gastrointestinal malignancies treated with 5-fluorouracil.

Clinica chimica acta; international journal of clinical chemistry·1994

Valproic acid, an epilepsy medication, increases birth defects in infants. Research explores its placental transfer, teratogenic potential, and effects on fetal development.

Area of Science:

  • Pharmacology
  • Developmental Toxicology
  • Teratology

Background:

  • Valproic acid is a key anticonvulsant for epilepsy management.
  • Prenatal exposure to valproic acid is linked to congenital abnormalities.

Purpose of the Study:

  • To review current knowledge on valproic acid's role in prenatal growth impairment.
  • To summarize clinical and research findings on valproic acid teratogenicity.

Main Methods:

  • Literature review of clinical studies and experimental research.
  • Analysis of placental transfer, teratogenic potential, and dose-response relationships.
  • Examination of species differences and fetal biochemical changes.

Main Results:

Related Experiment Videos

  • Valproic acid readily crosses the placenta.
  • Evidence supports its teratogenic potential with dose-dependent effects.
  • Species and strain variations influence susceptibility to valproic acid's effects.

    • Conclusions:

    • Valproic acid exposure during pregnancy poses significant risks for congenital abnormalities.
    • Understanding these risks is crucial for managing epilepsy in pregnant individuals.
    • Further research is needed to elucidate biochemical mechanisms and mitigate adverse effects.