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Related Concept Videos

Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

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Related Experiment Video

Updated: Jun 17, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

TCF1 and beta-catenin regulate T cell development and function.

Qing Yu1, Archna Sharma, Jyoti Misra Sen

  • 1Lymphocyte Development Unit, Laboratory of Immunology, National Institute on Aging, National Institutes of Health, BRC Building, 8C218, Baltimore, MD 21224, USA.

Immunologic Research
|January 19, 2010
PubMed
Summary
This summary is machine-generated.

T cell factor-1 (TCF1) and beta-catenin are crucial for T cell development and differentiation. Genetic manipulation revealed their essential roles in T cell receptor signaling pathways.

Related Experiment Videos

Last Updated: Jun 17, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

Area of Science:

  • Immunology
  • Molecular Biology
  • Developmental Biology

Background:

  • T cell factor-1 (TCF1) is vital for T cell development.
  • Signals controlling TCF1 function in T cells are largely unknown.
  • TCF1, with beta-catenin, regulates gene transcription and repression.

Purpose of the Study:

  • To investigate the signals controlling TCF1 function.
  • To elucidate the role of TCF1 and beta-catenin in T cell development and differentiation.
  • To explore the downstream effects of T cell receptor (TCR) signaling on TCF1 and beta-catenin.

Main Methods:

  • Genetic manipulation of the beta-catenin gene.
  • Generation of mutant mice.
  • Analysis of T cell development and differentiation stages.
  • Assessment of TCR signaling pathways.

Main Results:

  • Beta-catenin and TCF1 play essential roles during pre-TCR and TCR-dependent T cell development.
  • TCF1 and beta-catenin function downstream of TCR signaling.
  • TCF1 and beta-catenin are involved in CD4 T cell differentiation into T helper lineages.

Conclusions:

  • TCF1 and beta-catenin are critical regulators of T cell development and function.
  • TCR signaling modulates TCF1 and beta-catenin activity.
  • These findings provide insights into T cell lineage commitment and differentiation.