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Updated: Jun 17, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Intrahepatic cholangiocarcinoma resembling a thyroid follicular neoplasm
Adele Fornelli1, Arrigo Bondi, Elio Jovine
1Sezione Anatomia, Istologia e Citologia Patologica M. Malpighi, University of Bologna, Bologna, Italy.
Abstract:
The first case of well-differentiated intrahepatic cholangiocarcinoma with remarkable follicular architecture resembling a follicular neoplasm of thyroid is described in a 52-year-old man. The follicles contained homogenous eosinophilic material akin to colloid and were lined by benign-looking cuboidal cells. Immunohistochemically, thyroid transcription factor-1 (TTF-1) and thyroglobulin were negative and the patient had no evidence of a previous or concomitant thyroid tumour. This case can be added to the list of extrathyroid primary tumours that resemble thyroid neoplasms.
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